وَمَنْ أَضَلُّ مِمَّن يَدْعُوا۟ مِن دُونِ ٱللَّهِ مَن لَّا يَسْتَجِيبُ لَهُۥٓ إِلَىٰ يَوْمِ ٱلْقِيَٰمَةِ وَهُمْ عَن دُعَآئِهِمْ غَٰفِلُونَ
Wa man adallu mimmany yad'oo min doonil laahi mallaa yastajeebu lahooo ilaa Yawmil Qiyaamati wa hum'an du'aaa'ihim ghaafiloon
And who is more astray than he who invokes besides Allah those who will not respond to him until the Day of Resurrection, and they, of their invocation, are unaware.

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Tafsir

76%59%56%Al-JalalaynIbn AbbasIbn Kathir
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And who is man here is interrogative but meant rhetorically as a negation in other words ‘no one is’ further astray than him who invokes him who worships besides God that is to say other than Him such as would not respond to him even until the Day of Resurrection — these are the idols who never answer those who worship them in anything that they ask for — and who are heedless of their supplication? their worship because they are inanimates that possess no faculty of comprehension.

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About Quran 46:5