لَقَدْ كَفَرَ ٱلَّذِينَ قَالُوٓا۟ إِنَّ ٱللَّهَ هُوَ ٱلْمَسِيحُ ٱبْنُ مَرْيَمَ ۖ وَقَالَ ٱلْمَسِيحُ يَٰبَنِىٓ إِسْرَٰٓءِيلَ ٱعْبُدُوا۟ ٱللَّهَ رَبِّى وَرَبَّكُمْ ۖ إِنَّهُۥ مَن يُشْرِكْ بِٱللَّهِ فَقَدْ حَرَّمَ ٱللَّهُ عَلَيْهِ ٱلْجَنَّةَ وَمَأْوَىٰهُ ٱلنَّارُ ۖ وَمَا لِلظَّٰلِمِينَ مِنْ أَنصَارٍۢ
Laqad kafaral lazeena qaalooo innal laaha Huwal maseehub nu Maryama wa qaalal Maseehu yaa Baneee Israaa'eela budul laaha Rabbee wa Rabbakum innnahoo many-yushrik ballaahi faqad harramal laahu 'alaihil jannata wa maa waahun Naaru wa maa lizzaalimeena min ansaar
They have certainly disbelieved who say, "Allah is the Messiah, the son of Mary" while the Messiah has said, "O Children of Israel, worship Allah, my Lord and your Lord." Indeed, he who associates others with Allah - Allah has forbidden him Paradise, and his refuge is the Fire. And there are not for the wrongdoers any helpers.

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Tafsir

84%59%62%Al-JalalaynIbn AbbasIbn Kathir
Scholars largely agree on this ayah

They indeed are disbelievers those who say ‘Indeed God is the Messiah son of Mary’ a similar verse has preceded Q. 517. For the Messiah said to them ‘O Children of Israel worship God my Lord and your Lord for I am a servant and not a god. Verily he who associates anything with God in worship for him God has made Paradise forbidden He has forbidden him admittance to it and his abode shall be the Fire; and for wrongdoers wa-mā li’l-zālimīna min the min is extra there shall be no helpers’ to guard them against the chastisement of God.

Related Hadiths

Jami` at-Tirmidhi #3146Narrated Abu Hurairah:Da'if
"'Eisa was taught his argument, Allah taught him regarding His saying: And when Allah will say: 'O 'Eisa, son of Mariam! Did you say unto men 'Worship me and my mother as two gods besides Allah?'" Abu Hurairah narrated from the Messenger of Allah (ﷺ): "So Allah taught him: 'Glory be to You! It was not for me to say what I had no right (to say) (5:116).' The entire Ayah.
Sahih Muslim #47It is narrated on the authority of Ubadah b. Samit that the messenger of Allah (ﷺ) observed:Sahih
He who said:" There is no god but Allah, He is One and there is no associate with Him, that Muhammad is his servant and His messenger, that Christ is servant and the son of His slave-girl and he (Christ) His word which He communicated to Mary and is His Spirit, that Paradise is a fact and Hell is a fact," Allah would make him (he who affirms these truths enter Paradise through any one of its eight doors which he would like.
Sahih al-Bukhari #3359Narrated Abu Dhar:Sahih
The Prophet (ﷺ) said, "If somebody claims to be the son of any other than his real father knowingly, he but disbelieves in Allah, and if somebody claims to belong to some folk to whom he does not belong, let such a person take his place in the (Hell) Fire."
Sahih Muslim #174It is narrated on the authority of Abdullah b. Mas'ud that Waki told (him) that the Messenger of Allah had observed and Ibn Numair asserted:Sahih
I heard the Messenger of Allah (ﷺ) saying: He who dies associating anything with Allah would enter the Fire (of Hell). 'Abdullah b. Mas'ud said: I say that he who died without associating anything with Allah entered Paradise.
Sunan Ibn Majah #1836It was narrated from Abu Hurairah that the Prophet (ﷺ) said:Sahih
"Eisa bin Maryam saw a man stealing and said: 'Did you steal?' He said: 'No, by the One besides Whom there is no other God.' 'Eisa said: 'I believe in Allah, and I do not believe what my eyes see.'"

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About Quran 5:72