فَٱعْبُدُوا۟ مَا شِئْتُم مِّن دُونِهِۦ ۗ قُلْ إِنَّ ٱلْخَٰسِرِينَ ٱلَّذِينَ خَسِرُوٓا۟ أَنفُسَهُمْ وَأَهْلِيهِمْ يَوْمَ ٱلْقِيَٰمَةِ ۗ أَلَا ذَٰلِكَ هُوَ ٱلْخُسْرَانُ ٱلْمُبِينُ
Fa'budoo maa shi'tum min doonih; qul innal khaasireenal lazeena khasirooo anfusahum wa ahleehim yawmal qiyaamah; alaa zaalika huwal khusraanul mubeen
So worship what you will besides Him." Say, "Indeed, the losers are the ones who will lose themselves and their families on the Day of Resurrection. Unquestionably, that is the manifest loss."

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Tafsir

81%50%51%Al-JalalaynIbn AbbasIbn Kathir
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So worship whatever you wish besides Him’ other than Him — herein is a threat for them as well as a declaration of the fact that they do not worship God exalted be He. Say ‘Indeed the losers are those who will have lost their souls and their families on the Day of Resurrection by condemning their souls to abide forever in the Fire and their failure to attaining the bliss promised among the black-eyed virgins who would have been prepared for them in Paradise had they been believers. Truly that is the manifest loss!’

Related Hadiths

Sunan Ibn Majah #3703It was narrated from Abu Umamah that the Messenger of Allah (ﷺ) said:Hasan
“Among the worst people in status before Allah on the Day of Resurrection will be a person who loses his Hereafter for the sake of this world.”
Sahih al-Bukhari #6396Narrated Abu Dhar:Sahih
I reached him (the Prophet (ﷺ) ) while in the shade of the Ka`ba; he was saying, "They are the losers, by the Lord of the Ka`ba! They are the losers, by the Lord of the Ka`ba!" I said (to myself ), "What is wrong with me? Is anything improper detected in me? What is wrong with me? Then I sat beside him and he kept on saying his statement. I could not remain quiet, and Allah knows in what sorrowful state I was at that time. So I said, ' Who are they (the losers)? Let My father and mother be sacrificed for you, O Allah's Messenger (ﷺ)!" He said, "They are the wealthy people, except the one who does like this and like this and like this (i.e., spends of his wealth in Allah's Cause).
Sahih Muslim #2184Abu Dharr reported:Sahih
I went to the Messenger of Allah (ﷺ) and he was sitting under the shade of the Ka'ba. As he saw me he said: By the Lord of the Ka'ba, they are the losers. I came there till I sat and I could not stay (longer) and (then) stood up. I said: Messenger of Allah, let my father, be ransom for you, who are they (the losers)? He said: They are those having a huge amount of wealth except so and so and (those who spend their wealth generously on them whom they find in front of them, behind them and on their right side and on their left side) and they are a few. And no owner of camels, or cattle or goat and sheep, who does not pay Zakat (would be spared punishment) but these (camels, cattle, goats and sheep) would come on the Day of Resurrection wearing more flesh and would gore him with their horns and trample them with their hooves. And when the last one would pass away, the first one would return (to trample him) till judgment would be pronounced among people.
Sahih al-Bukhari #1202Narrated `Abdullah:Sahih
Allah's Messenger (ﷺ) said, "Anyone who dies worshipping others along with Allah will definitely enter the Fire." I said, "Anyone who dies worshipping none along with Allah will definitely enter Paradise."
Sahih al-Bukhari #540Narrated Ibn `Umar:Sahih
Allah's Messenger (ﷺ) said, "Whoever misses the `Asr prayer (intentionally) then it is as if he lost his family and property."

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About Quran 39:15