مَّا كَانَ مُحَمَّدٌ أَبَآ أَحَدٍۢ مِّن رِّجَالِكُمْ وَلَٰكِن رَّسُولَ ٱللَّهِ وَخَاتَمَ ٱلنَّبِيِّۦنَ ۗ وَكَانَ ٱللَّهُ بِكُلِّ شَىْءٍ عَلِيمًۭا
Maa kaana Muhammmadun abaaa ahadim mir rijaalikum wa laakir Rasoolal laahi wa Khaataman Nabiyyeen; wa kaanal laahu bikulli shai'in 'Aleema
Muhammad is not the father of [any] one of your men, but [he is] the Messenger of Allah and last of the prophets. And ever is Allah, of all things, Knowing.

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Tafsir

84%58%56%Al-JalalaynIbn AbbasIbn Kathir
Scholars offer complementary perspectives

Muhammad is not the father of any man among you he is not Zayd’s biological father and so it is not unlawful for him to marry his former wife Zaynab after him; but he is the Messenger of God and the Seal of the Prophets and so he will not have a son that is a fully grown man to be a prophet after him a variant reading for khātim al-nabiyyīna has khātam al-nabiyyīn as in the instrument known as a ‘seal’ in other words their prophethood has been sealed by him. And God has knowledge of all things among these is the fact that there will be no prophet after him and even when the lord Jesus descends at the end of days he will rule according to his Muhammad’s Law.

Related Hadiths

Sahih Muslim #5343Anas reported that when Allah's Apostle (ﷺ) decided to write to the Kisra (the King of Persia), Caesar (Emperor of Rome), and the Negus (the Emperor of Abyssinia), it was said to him that they would not accept the letter without the seal over it; so Allah's Messenger (ﷺ) got a seal made, the ring of which was made of silver and there was engraved on it:Sahih
"Muhammad, the Messenger of Allah."
Sahih al-Bukhari #3512'Aisha said (in another narration), ("When the Prophet (ﷺ) was on his death-bed) he looked up and said thrice, (Amongst) the Highest Companion (See Qur'an 4.69)' Aisha said, Allah benefited the people by their two speeches. 'Umar frightened the people some of whom were hypocrites whom Allah caused to abandon Islam because of 'Umar's speech. Then Abu Bakr led the people to True Guidance and acquainted them with the right path they were to follow so that they went out reciting:Sahih
-- "Muhammad is no more than an Apostle and indeed many Apostles have passed away before him.." (3.144)
Sahih Muslim #5964Anas b. Malik reported that a person said:Sahih
Allah's Messenger, who is my father? And he said: Your father is so and so, and there was revealed this verse:" Do not ask about matters which, if they were to be made manifest to you, might cause you harm" (v. 101).
Jami` at-Tirmidhi #3294Narrated Dawud bin Abi Hind:Hasan
from Ash-Sha'bi regarding the saying of Allah : 'Muhammad is not the father of any one of your men (33:40)' he said: "No male children of his would live among them."
Sunan Ibn Majah #3377It was narrated from Anas bin Malik that the Messenger of Allah (ﷺ) wore a ring of silver, in which was an Ethiopian gemstone and the inscription:Sahih
‘Muhammad Rasul Allah’ (Muhammad the Messenger of Allah).”

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About Quran 33:40